Solid galenics
Galenics - named after the Greek physician Galenos - is the study of the preparation and administration of medicines. The aim is to prepare active ingredients in such a way that they are safe, effective, user-friendly and stable in storage. Galenic forms range from liquid solutions and semi-solid gels to solid forms such as powders, tablets or capsules. Solid galenics deals with the development and production of solid dosage forms.
In solid dosage forms, active pharmaceutical ingredients are converted into a solid dosage form that enables precise dosing, easy handling and targeted release in the body.
Typical galenic finished medicinal products are
- Tablets (also effervescent or melting tablets)
- Hard and soft gelatine capsules
- Bag with powder or granules
- Pellets, microcapsules, lozenges or chewable tablets
- Agglomerates from spraying or fluidised bed processes
The manufacture of such products requires that the active ingredients are available in a suitable purity, particle size and concentration. In addition, excipients such as fillers, binders, lubricants or flavour correctors must be incorporated. This often leads to complex process routes with several process steps.
The mixing process plays a central role in solid galenics: active ingredients and excipients must be homogeneously distributed without impairing their sensitive properties. The amixon® mixers are precisely tailored to these requirements. They enable gentle, reproducible and hygienic homogenisation of even the most sensitive active ingredient systems.
amixon® technology in solid galenics:
- Six different mixing principles for specific requirements
- Batch sizes from a few litres up to 100 m³ (rather rare).
- Ideal for formulation development, pilot and large batch production
- Typical production sizes from 2 to 8 m³
- Hygienic design, CIP/SIP-capable, GMP-compliant
- Almost complete emptying of residues, even with sticky or fine-grained powders
amixon® mixers not only support the production of classic dosage forms, but also related applications such as food supplements, dietary foods, probiotic preparations and nutraceuticals. They offer the necessary flexibility to cover a wide range of application and packaging forms as well as output quantities - reliably, efficiently and pharmaceutically flawlessly.
Technical centres in China, India, Japan, Korea, Germany and the USA can demonstrate mixing processes.