Cross-contamination

Cross-contamination refers to the unwanted transfer of microorganisms, chemical substances, particles, or allergens from one material, surface, or process to another. As a result, a product that is actually “clean” becomes contaminated. This can occur directly (e.g., through the shared use of mixers, containers, or tools) or indirectly via air, dust deposits, clothing, packaging, or inadequately cleaned peripheral equipment.

In practice, cross-contamination can be quantitatively assessed using MACO calculations. These represent the permissible residual amount of an active ingredient on contact surfaces after cleaning. This amount could inadvertently be carried over into the next product.

In food, pharmaceutical, and cosmetic production, preventing cross-contamination is a central requirement to avoid health risks (e.g., due to allergens or toxic active ingredients) and quality defects. For amixon® powder mixers, this means: hygienic, easy-to-clean geometries; equipment that can be completely emptied; well-conceived product changeover and cleaning strategies; and – where necessary – containment and docking systems that prevent powders or dust from being carried over into other product streams or the work area.